Cyclobenzaprine: What Is It? Side Effects & Interactions Cleveland Clinic

For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended.

Laboratory data were classified as low, normal, or high and out-of-range values were flagged. Within-group values for numeric variables were summarized. Scatterplots were generated for selected laboratory tests.

General drug facts

A comprehensive treatment program should consist of traditional and alternative therapies. Flexeril is also taken to come down from stimulants such as Adderall or cocaine. However, a person who struggles with substance use disorder may have withdrawal symptoms if they stop or reduce their dose.

CBP was formulated as 1 mg capsules, and placebo capsules contained no CBP. Investigators were allowed to adjust dosage throughout the study as tolerability allowed. Daily dose ranged from 2 to 4 mg in the VLD CBP group at Week 8, with a group mean of 3.1 mg. Placebo capsules were titrated to a dose corresponding to 2.1 mg.

Overtaking Flexeril, even in the daily recommended dose, can lead to uncomfortable side effects such as dry mouth, headaches, drowsiness, fatigue, and stomach pain. In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended.

• It isn’t known exactly how this drug works to relax your muscles.
• It is generally used for musculoskeletal conditions, including fibromyalgia and low back pain.
• Lastly, people with a prescription for Flexeril can build a tolerance to Flexeril.
• Your care team will tell you how much medication to take.

There is a variety of treatment settings for Flexeril addiction. However, not all people struggling with Flexeril addiction need to detox medically. But, if you also struggle with alcohol use disorder, medical detox may be necessary. Prescription drugs like Flexeril are widely misused among all age groups. For example, SAMHSA reports that misuse is increasing in adults over 50. This increase is concerning due to the harmful effects of drugs like Flexeril in this age group.

What is this drug used for?

Other potential effects of overdosage include any of the symptoms listed under ADVERSE REACTIONS. It is not known whether this drug is excreted in human milk. Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when FLEXERIL is administered to a nursing woman. Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Sana Lake Recovery Center is a Joint Commission Accredited addiction treatment program. We offer a safe and trustworthy facility for people struggling with substance abuse.

Although withdrawal symptoms are generally mild, they may include headaches, nausea, and craving. Most doctors and professionals consider Flexeril to be non-addictive. Some people like the depressive effects of the central nervous system.

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Anyone with a history of substance abuse should mention this medical history to their doctor. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval. Of 37 patients with FM in the screened population, 36 were randomized and treated in this 8-week, double-blind, placebo-controlled, dose-escalating study of VLD CBP 1–4 mg at bedtime.

Evidence of Effectiveness

Also, cyclobenzaprine can cause dry mouth because it has anticholinergic effects. Cyclobenzaprine (Flexeril) is structurally similar to TCAs generic for flexeril cyclobenzaprine and, as such, demonstrates significant anticholinergic side effects. It differs from the TCA amitriptyline by only one double bond.